During pandemic situation, safety and security play a major role in maintaining a person’s health and well-being. The safe and secure environment influences social habits, reduces stress (feeling of freedom) and increases health protection. When people feel safe, they find it easier to relax, do all the things that comfort and focus on the work. The ultimate goal of this paper is on the complete integration of the sanitizer dispenser into the door lock system to monitor the home using a smartphone with hand hygiene for advanced safety and security against any anomalies that have been detected in houses, office buildings and various construction sites—everywhere there is a need for advanced frontline security. The door lock system opts security by allowing the owner to control the buildings with a Bluetooth-connected smartphone-controlled system using Arduino UNO with an android application developed and opts for safety by using the sanitizer dispenser with PIR sensor by force cleaning the user’s hands to open or close the door lock. In this method, the users should provide valid login credentials in the application which is verified with the database over the Internet and sanitize the user’s hands before permitting entry, thereby reducing the spread of germs. If the credentials are invalid or if the sanitizer is not used buzzer rings and an SMS alert will be sent to the owner of the building and keeps the door locked which enhances the security along with safety or hygiene.