Biodegradable films and blends are obtained from various macromolecules including proteins, lipids, and polysaccharides, etc. Among these, proteins are highly preferred materials due to their high capacity for forming intermolecular bonds, which are required for film formation and are biodegradable. The protein-based films and blends are produced through either a dry or wet process, which has a significant effect on the properties of the resulting material. Moreover, the dry process is not commonly used to produce biodegradable films and blends, because they lack specified melting points and decompose when heated. The biodegradable blends offer superior properties to the pure polymers due to a synergistic effect between them. This chapter provides an overview of the properties of protein-based biodegradable films and blends made using various techniques. Furthermore, the protein sources and potential applications of protein-based blends and films are also presented.