Recent discovery and development of inhibitors targeting coronaviruses

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Manoj, M (2020) Recent discovery and development of inhibitors targeting coronaviruses. Drug Discovery Today, 25 (4). pp. 668-688. ISSN 13596446

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Official URL: https://doi.org/10.1016/j.drudis.2020.01.015

Abstract

Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. Currently, six human CoVs have been reported including human coronavirus 229E (HCoV-229E), OC43 (HCoV-OC43), NL63 (HCoV-NL63), HKU1 (HCoV-HKU1), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV), and MiddleEast respiratory syndrome (MERS) coronavirus (MERS-CoV). They cause moderate to severe respiratory and intestinal infections in humans. In this review, we focus on recent advances in the research and development of small-molecule anti-human coronavirus therapies targeting different stages of the CoV life cycle. Recent advances in the research and development of small-molecule anti-human coronavirus therapies.

Item Type:	Article
Subjects:	G Chemistry > Organic chemistry
Divisions:	Chemistry
Depositing User:	Users 5 not found.
Date Deposited:	12 Apr 2024 09:03
Last Modified:	12 Apr 2024 09:03
URI:	https://ir.psgitech.ac.in/id/eprint/294

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