Duplex stainless steel (DSS) 2205 is widely used in oil and gas infrastructure for its excellent mechanical strength and corrosion resistance; however, erosive flow conditions can severely degrade its surface and compromise performance. This study employs the Taguchi design of experiments to optimize corrosion resistance of eroded DSS 2205 in simulated oil and gas environments. Slurry erosion tests followed by potentiodynamic polarization revealed that optimized conditions—150 m/s impact velocity, 5 g/min erodent feed rate, and a 90° impingement angle—reduced the corrosion rate by up to 50%. Analysis of variance (ANOVA) confirmed the statistical significance of these parameters. Surface analysis using SEM and profilometry supported the electrochemical findings by showing reduced erosion damage under optimized conditions. The practical significance of this work lies in its data-driven framework for mitigating erosion–corrosion synergy, offering valuable guidance for enhancing the durability and service life of DSS components in aggressive oil and gas environments. © 2025 Informa UK Limited, trading as Taylor & Francis Group.