The use of digital media among student community has increased their level of distraction during classroom teaching. Capturing their attention in classrooms, has become a cumbersome task for teaching faculty. Therefore, most of the academic institutions have resorted to the use of activity-based learning for science and engineering students that were originally used for teaching school students. This paper presents a comparative study on the effectiveness of different teaching learning methods applied to three groups of engineering students in Computer Science and Bio-Technology, evaluated by conducting tests and feedbacks. Also, a comparative study was performed to assess the effectiveness of conventional and modern evaluation tools. The results show that the subject understanding level of the students increased by 67–76% when any of the activity-based learning method was used. The study confirms the potential use of activity-based method for teaching learning and ICT tools for performance evaluation, for engineering students.