The incorporation of vortex generators in the microchannel proved to be effective in dissipating heat and has become a hot topic for decades. This numerical study compares the heat dissipation performance of eight vortex generators (VGs) incorporated in microchannels with water as the coolant. The thermo-hydraulic performance of the channel with selected VGs were studied. Microchannel with hydraulic diameter of 500 μm was used with 13 pairs of VGs of each type arranged in the flow direction, respectively. The heat transfer analysis with coolant flow was conducted on each of these microchannel at Reynolds numbers 100, 200, 300, 400, and 500. Two arrangements: bottom wall and sidewall arrangements were studied separately. The results indicated that all vortex generators enhanced the heat dissipation performance with Reynolds number with the penalty of pressure drop. The studies proved that both bottom and side wall arrangements of VGs significantly improved Nusselt number of the channel but the side wall fetched the highest pressure drop of 49.29% at Re = 500.