The Tissue Mimicking Materials (TMM), are widely used in medical research, training, clinical simulators etc., to simulate the properties which are much more similar to that of the real biological tissues. In medical research TMM plays a vital role as the idealized tissue models to design and to test the methods, systems and clinical tools etc. In general TMM are made from bio polymers (agar, agarose, gelatin and gellan gum) and chemically synthesized polymers (polyvinyl alcohol, polymerized siloxanes, poly vinyl chlorides). The bio polymers have the properties of high mass fraction of water (>80%), due to this these biopolymers are not stable for long term use and also have a bacterial growth in a material. On the other hand, the chemically synthesized polymers have a lack of less similar properties to that of the skin. Ratio of softener and polymer, mass fraction of mineral oil and micronized glass beads are factors playing the major role in deciding the properties of TMM. Moreover, by using these TMM the mechanics of needle insertion such as applied force, friction between the needle and tissue and velocity of insertion etc. are studied to use it effectively in clinical applications. Even though, quite number of TMM are developed and tested, the TMM having properties which are very closer to real biological tissue at different aging periods are not available. Therefore, the researchers are working continuously to develop such kind of materials and it needs a depth understanding of available materials and its properties. This paper focuses on presenting a detailed literature study on development and characterization of various TMM, which will be useful for the researchers to develop new TMM for clinical training and clinical tool testing applications