Millimetre wave (mm-wave) communication and Multiple Input Multiple Output (MIMO) systems are promising solutions to overcome the challenge possessed by the future wireless systems. Spatial Modulation (SM) techniques has the inherent potential to overcome the drawbacks of MIMO systems such as increased energy consumption, complexity and cost. Quadrature Spatial Modulation (QSM) is another type of spatial modulation technique and it helps in enhancing the spectral efficiency achieved by Spatial Modulation (SM) by transmitting additional base 2 logarithm of Nt bits and it retains all other advantages of SM. A novel Generalized QSM (GQSM) aided mm-wave MIMO structure is proposed in this paper. In order to select the antenna combinations in GQSM a virtual antenna grouping is performed. The analytical and simulated average BER of the proposed system are compared to analyse its performance. Also, the average BER performance of the proposed system outperforms the GSM aided mm-wave MIMO and QSM aided mm-wave MIMO systems.